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Abstract Title:

Curcumin inhibits Jurkat cell proliferation by inducing apoptosis via activation-induced cell death.

Abstract Source:

Trends Endocrinol Metab. 2009 Apr;20(3):139-45. Epub 2009 Mar 9. PMID: 20863651

Abstract Author(s):

V S Yadav, K P Mishra, D P Singh

Article Affiliation:

Department of Immunology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

Abstract:

The effects of curcumin on cell proliferation, activation-induced cell death (AICD) and expression of interleukin-2 (IL-2) receptors (IL-2Rα, CD25) by Jurkat cells were investigated. Incubation of Jurkat cells for 72h with either phytohaemagglutinin (PHA) or curcumin (2.5μg/mL) resulted in marked inhibition of cell proliferation, determined by (3)H-thymidine incorporation. The anticancer activity of curcumin was also confirmed by quantitating the PHA-induced AICD in Jurkat cells by flow cytometry. It was found that curcumin (2.5μg/mL) enhanced apoptosis in PHA-treated Jurkat cells. Further we observed the level of CD25 expression on Jurkat cells by flow cytometry. Our data indicate that curcumin inhibited PHA-induced CD25 expression. The present study suggests that curcumin have potent anticancer activities, which might be useful in lymphoma treatment.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Apoptotic : CK(5217) : AC(3846)

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Sayer Ji
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