Abstract Title:

Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway.

Abstract Source:

FEBS Lett. 2009 Dec 17. PMID: 20026048

Abstract Author(s):

Kyeongjin Kim, Kook Hwan Kim, Hye Young Kim, Hyun Kook Cho, Naoya Sakamoto, Jaehun Cheong


A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-kappaB pathway. The combination of curcumin and IFNalpha exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents. Copyright © 2009. Published by Elsevier B.V.

Study Type : In Vitro Study, Viral

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Sayer Ji
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