Abstract Title:

Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line.

Abstract Source:

J Urol. 2011 Feb;185(2):719-24. Epub 2010 Dec 18. PMID: 12104041

Abstract Author(s):

Cheppail Ramachandran, Hugo B Fonseca, Perseus Jhabvala, Enrique A Escalon, Steven J Melnick

Article Affiliation:

Department of Pathology, Miami Children's Hospital, 3100 SW 62nd Avenue, FL 33155, USA. cheppail.ramachandran@mch.com

Abstract:

The inhibitory effect of curcumin, the yellow-colored pigment from turmeric, on telomerase activity was analyzed in human mammary epithelial (MCF-10A) and breast cancer (MCF-7) cells. Telomerase activity in MCF-7 cells is 6.9-fold higher than that of human mammary epithelial cells. In MCF-7 cells, telomerase activity decreased with increasing concentrations of curcumin, inhibiting about 93.4% activity at 100 microM concentration. The inhibition of telomerase activity in MCF-7 cells may be due to down-regulation of hTERT expression. Increasing concentrations of curcumin caused a steady decrease in the level of hTERT mRNA in MCF-7 cells whereas the level of hTER and c-myc mRNAs remained the same. Our results suggest that curcumin inhibits telomerase activity by down-regulating hTERT expression in breast cancer cells and this down-regulation is not through the c-myc pathway.

Study Type : In Vitro Study

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