Abstract Title:

Metabolic intervention of aflatoxin B1 toxicity by curcumin.

Abstract Source:

J Ethnopharmacol. 2010 Feb 17;127(3):641-4. Epub 2009 Dec 14. PMID: 20015472

Abstract Author(s):

Sujatha Nayak, R B Sashidhar

Article Affiliation:

Department of Biochemistry, University College of Science, Osmania University, Hyderabad, AP, India.

Abstract:

UNLABELLED: ETHNO PHARMACOLOGICAL RELEVANCE: Curcumin, bioactive principle of turmeric (Curcuma longa Linn) is an important constituent of Indian traditional medicine. Turmeric has been known to possess several therapeutic properties.

AIM OF THE STUDY: The modulatory effect of dietary curcumin (0.05%, w/w) on drug metabolizing and general marker enzymes of liver and formation of AFB(1)-adducts (DNA and protein) due to dietary AFB(1) exposure for a period of 6 weeks in a rodent model, have been evaluated.

MATERIALS AND METHODS: Drug metabolizing enzymes CYP1A1, GSHT, UGT1A and general marker enzymes (LDH, ALT, AST, ALP and gamma-GT) of liver were estimated by standardized methods. Aflatoxin adducts (DNA and protein) were quantitated by indirect competitive ELISA.

RESULTS: Dietary curcumin enhanced GSHT (p<0.001) and UGT1A1 (p<0.05) activity and significantly reduced the activity of CYP1A1 (p<0.001), in rats exposed to aflatoxin B(1). Supplementation of curcumin in the diet normalized the altered activities of LDH and ALT. At molecular level, curcumin significantly reduced AFB(1)-N(7)-guanine adduct (p<0.001) excretion in the urine, DNA adduct (p<0.05) in the liver and albumin adduct (p<0.001) in the serum.

CONCLUSION: The experimental results substantiates that curcumin intervention ameliorates the AFB(1) induced toxicity.

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.