Abstract Title:

Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer.

Abstract Source:

Phytother Res. 2008 Sep 23. PMID: 19058955

Abstract Author(s):

Krystal Madden, Lisa Flowers, Ritu Salani, Ira Horowitz, Sanjay Logan, Kevin Kowalski, Jun Xie, Sulma I Mohammed

Article Affiliation:

Department of Comparative Pathobiology, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA.

Abstract:

Cervical cancer is the second leading cause of cancer death for women in the world. A potential target for preventing and treating cervical cancer is cyclooxygenase-2 (cox-2). Curcumin is an anti-inflammatory agent that is known to have anti-cox-2 activity. In this study we examined the expression of cox-2 in cervical cancer and its precursors by immunohistochemistry. The effect of curcumin in inhibiting cervical cancer cells was determined via 2-dimensional gel electrophoresis, data analysis, and ingenuity pathway analysis. No significant differences in the expression of cox-2 in squamous cell carcinoma, and carcinoma in situ were observed. However, there was a statistically significant difference in the expression of cox-2 in adenocarcinoma in comparison to normal (p value=0.01) and squamous cell carcinoma (p value=0.02) tissues. Proteins associated with cancer and cell cycle were significantly altered in cultured cells. Curcumin may have antitumor effect in cervical cancer.

Study Type : In Vitro Study

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Sayer Ji
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