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Abstract Title:

Curcumin: a modulator of inflammatory signaling pathways in the immune system.

Abstract Source:

Inflammopharmacology. 2019 Oct ;27(5):885-900. Epub 2019 May 28. PMID: 31140036

Abstract Author(s):

Kolsoum Rezaie Kahkhaie, Ali Mirhosseini, Ali Aliabadi, Asadollah Mohammadi, Mohammad Javad Mousavi, Saeed Mohammadian Haftcheshmeh, Thozhukat Sathyapalan, Amirhossein Sahebkar

Article Affiliation:

Kolsoum Rezaie Kahkhaie

Abstract:

Curcumin is a natural compound derived from the spice, turmeric, that has been extensively reported for its efficacy in controlling or treatment of several inflammatory diseases. There is a growing body of literature that recognizes the anti-inflammatory effects of curcumin in the immune system. On the other hand, the role of inflammatory signaling pathways has been highlighted in the pathogenesis of several inflammatory diseases, and signaling molecules involved in these pathways are considered as valuable targets for new treatment approaches. We aimed to provide a comprehensive overview of the modulatory effects of curcumin on inflammatory signaling pathways which leads to inhibition of inflammation in different types of immune cells and animal models. In this comprehensive review, we elaborate on how curcumin can effectively inhibit multiple signaling molecules involved in inflammation including NF-κB, JAKs/STATs, MAPKs, β-catenin, and Notch-1.

Study Type : Review

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