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Article Publish Status: FREE
Abstract Title:

Curcumin prevents chronic intermittent hypoxia-induced myocardial injury.

Abstract Source:

Ther Adv Chronic Dis. 2020 ;11:2040622320922104. Epub 2020 Jun 24. PMID: 32637058

Abstract Author(s):

Sophie Moulin, Claire Arnaud, Sophie Bouyon, Jean-Louis Pépin, Diane Godin-Ribuot, Elise Belaidi

Article Affiliation:

Sophie Moulin

Abstract:

Background: Chronic intermittent hypoxia (IH), the hallmark feature of obstructive sleep apnoea syndrome, contributes to infarct size enhancement after myocardial ischemia-reperfusion (I/R). Curcumin (Curc), the natural pigment of, has been demonstrated to be beneficial in the context of myocardial injury. In this study, we assessed the effects of Curc on the maladaptive cardiac response to IH, and particularly on IH-induced hypoxia inducible factor-1 (HIF-1) expression, oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis.

Methods: Swiss/SV129 mice were exposed to normoxia or IH (21-5% FiO, 60 s cycles, 8 h per day, for 21 days) and treated orally with Curc (100 mg kgday, oral gavage) or its vehicle. Mice were then either euthanised for heart sampling in order to perform biochemical and histological analysis, or subjected to anischemia-reperfusion protocol in order to measure infarct size.

Results: IH increased nuclear HIF-1α expression and superoxide anion (O) production as well as nuclear factor kappa B (NF-kB) p65, glucose-regulated protein (Grp78) and C/EBP homologous protein (CHOP) expression. IH also induced apoptosis and increased infarct size after I/R . The IH-induced HIF-1 activation, oxidative stress, inflammation, ER stress and apoptosis were abolished by chronic Curc treatment. Curc also significantly decreased infarct size only in mice exposed to IH.

Conclusion: Curc prevents IH-induced myocardial cell death signalling. Curc might be used as a combined therapy with continuous positive airway pressure in sleep apnoea patients with high cardiovascular risk.

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