Abstract Title:

Curcumin prevents cigarette smoke extract induced cognitive impairment.

Abstract Source:

Front Biosci (Elite Ed). 2019 Jan 1 ;11:109-120. Epub 2019 Jan 1. PMID: 30468642

Abstract Author(s):

Arunachalam Muthuraman, Loganathan Thilagavathi, Sara Jabeen, Shreyas Belagod Ravishankar, Syed Shakeeb Ahmed, Thomas George, Narahari Rishitha, Nallupillai Paramakrishnan

Article Affiliation:

Arunachalam Muthuraman


Curcumin is a major phytochemical constituent inan herbaceous perennial plant offamily, which exhibits anti-oxidant, anti-inflammatory and immunomodulatory properties. Here, we studied the therapeutic action of curcumin against CSE induced cognitive impairment in zebrafish. Montelukast (20 mg/kg), a cysteinyl-leukotriene receptor blocker was used as a reference drug. CSE exposure induced biochemical changes revealed that raise the brain acetylcholinesterase activity and lipid peroxidative products; and decrease the reduced glutathione levels in brain samples. Curcumin also protected against CSE induced neurocognitive impairment. These data suggest that curcumin can serve as a phytochemical constituent against CSE induced neurocognitive impairment.

Study Type : Animal Study

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