Abstract Title:

Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway.

Abstract Source:

Biochem Biophys Res Commun. 2010 Aug 13;399(1):1-6. Epub 2010 Jul 11. PMID: 20627087

Abstract Author(s):

Jian Zhang, Tao Zhang, Xinyu Ti, Jieran Shi, Changgui Wu, Xinling Ren, Hong Yin

Article Affiliation:

Department of Respiratory Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, China. zhangjian197011@yahoo.com

Abstract:

Curcumin extracted from the rhizomes of Curcuma longa L. has been shown to have inhibitory effects on cancers through its anti-proliferative and pro-apoptotic activities. Emerging evidence demonstrates that curcumin can overcome drug resistance to classical chemotherapies. Thus, the mechanisms underlying the anti-tumor activities of curcumin require further study. In our study, we first demonstrated that curcumin had anti-cancer effects on A549/DDP multidrug-resistant human lung adenocarcinoma cells. Further studies showed that curcumin altered miRNA expression; in particular, significantly downregulated the expression of miR-186 * in A549/DDP. In addition, transfection of cells with a miR-186 * inhibitor promoted A549/DDP apoptosis, and overexpression of miR-186 * significantly inhibited curcumin-induced apoptosis in A549/DDP cells. These observations suggest that miR-186 * may serve as a potential gene therapy target for refractory lung cancer that is sensitive to curcumin.

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