Curcumin protects against experimental liver injury in mice. - GreenMedInfo Summary
[Protective effect of curcumin on experimental liver injury in mice].
Zhongguo Zhong Yao Za Zhi. 2003 Aug;28(8):756-8, 793. PMID: 15015361
Department of Pharmacology, First Military Medical University, Guangzhou 510515, Guandong, China.
OBJECTIVE: To Study the protective effect of curcumin on three models of experimental liver injury in mice.
METHOD: The experimental models of live injury were induced by carbon tetrachloride (CCl4), D-galactosamine (D-Gal N), and Bacillus Calmette-Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice.
RESULT: Curcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.
CONCLUSION: Curcumin showed protective effect against liver injury induced by CCl4, D-Gal N, BCG plus LPS.