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Abstract Title:

Effect of curcumin on pathogenesis of hamster-opisthorchiasis through apoptosis-related gene expression.

Abstract Source:

Southeast Asian J Trop Med Public Health. 2009 Nov;40(6):1208-15. PMID: 20578454

Abstract Author(s):

Pranee Sriraj, Thidarut Boonmars, Sirintip Boonjaraspinyo, Butsara Kaewsamut, Tuanchai Srisawangwong, Paiboon Sithithaworn, Zhiliang Wu

Article Affiliation:

Faculty of Medical Technology, Rangsit University, Pathum Thani.

Abstract:

The present study investigated the effect of curcumin, a phenolic compound with yellow color from Curcuma longa L., on the expression of the apoptosis-related genes [BAX (Bcl-2 associated protein X), PKB, p53, MDM2 (mouse double minute 2), caspase 9, c-Ski, smad1 and smad4] in hamster opisthorchiasis. On Opisthorchis viverrini infection treated with dietary curcumin apoptosis-related gene expression profiles were similar to O. viverrini-infected group, but the expression levels seemed lower. Light microscopic observation revealed that aggregation of inflammatory cells surrounding the hepatic bile ducts in the groups infected with O. viverrini and treated with dietary curcumin was lower than in infected group. The intensity of the response is correlated with expression of the genes studied. The results suggest that curcumin reduces pathogenesis in hamster-opisthorchiasis by controlling apoptosis-related gene expression.

Study Type : Animal Study

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Sayer Ji
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