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Abstract Title:

[Empirical study of reverse effect on mediated multidrug resistance of U-2OS/ADM cells with curcumin in vitro].

Abstract Source:

Wei Sheng Yan Jiu. 2011 Jan;40(1):103-6. PMID: 21434326

Abstract Author(s):

Yang Xiao, Wanchun Wang

Article Affiliation:

Loudi Municipal Central Hospital of Hunan Province, Loudi 417000, China. Xiao_Yang168@sina.com

Abstract:

OBJECTIVE: To investigate the reversion of P-gp mediated multidrug resistance of U-2OS/ADM cells with curcumin in vitro.

METHODS: With doxorubicin as induction drugs, human osteosarcoma cell line U-2OS was induced object, multi-drug resistant of human osteosarcoma cell line model (U-2OS/ADM) were established by high-dose method, The before and after reversal efficacy of curcumin for U-2OS/ADM cells to chemotherapeutic drugs were measured by MTT assay. The effects of curcumin on Rh-123 uptake and efflux were analyzed by flow cytometer.

RESULTS: (1) MTT demonstrates curcumin (20 micromol/L) can increase the cytotoxicity of Adriamycin to U-2OS/ADM cells. (2) The result of FCM shows that Curcumin can increase the accumulation of Rh-123 and increase the cytotoxicity of Adriamycin to U-2OS/ADM cells in a dose-dependent manner.

CONCLUSION: The reversal mechanism of curcumin was blocked the function of P-gp in U-2OS/ADM cellular membrane.

Study Type : In Vitro Study

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