Curcumin treatment improves motor behavior in α-synuclein transgenic mice. - GreenMedInfo Summary
Curcumin Treatment Improves Motor Behavior inα-Synuclein Transgenic Mice.
PLoS One. 2015 ;10(6):e0128510. Epub 2015 Jun 2. PMID: 26035833
Kateri J Spinelli
The curry spice curcumin plays a protective role in mouse models of neurodegenerative diseases, and can also directly modulate aggregation ofα-synuclein protein in vitro, yet no studies have described the interaction of curcumin and α-synuclein in genetic synucleinopathy mouse models. Here we examined the effect of chronic and acute curcumin treatment in the Syn-GFP mouse line, which overexpresses wild-type human α-synuclein protein.We discovered that curcumin diet intervention significantly improved gait impairments and resulted in an increase in phosphorylated forms of α-synuclein at cortical presynaptic terminals. Acute curcumin treatment also caused an increase in phosphorylated α-synuclein in terminals, but had no directeffect on α-synuclein aggregation, as measured by in vivo multiphoton imaging and Proteinase-K digestion. Using LC-MS/MS, we detected ~5 ng/mL and ~12 ng/mL free curcumin in the plasma of chronic or acutely treated mice, with a glucuronidation rate of 94% and 97%, respectively. Despite the low plasma levels and extensive metabolism of curcumin, these results show that dietary curcumin intervention correlates with significant behavioral and molecular changes in a genetic synucleinopathy mouse model that mimics human disease.