Abstract Title:

Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria.

Abstract Source:

J Nat Prod. 1998 Dec;61(12):1531-4. PMID: 9868158

Abstract Author(s):

W J Syu, C C Shen, M J Don, J C Ou, G H Lee, C M Sun

Article Affiliation:

Institute of Microbiology and Immunology, National Yang-Ming University, Taipei.

Abstract:

Bioassay-directed fractionation of an EtOH extract of Curcuma zedoaria led to isolation of an active curcuminoid, which was identified as demethoxycurcumin (2) by comparison of its 1H and 13C NMR spectra with literature data and by direct comparison with synthetic material. Curcumin (1) and bisdemethoxycurcumin (3) were also obtained. Curcuminoids (1-3) were synthesized and demonstrated to be cytotoxic against human ovarian cancer OVCAR-3 cells. The observed CD50 values of 1, 2, and 3 were 4.4, 3.8, and 3.1 microg/mL, respectively. Three additional novel compounds, 3, 7-dimethylindan-5-carboxylic acid (4), curcolonol (5), and guaidiol (6), were also isolated from the EtOH extract. The structures and relative stereochemistry of 4-6 were determined by spectroscopic methods and X-ray crystallographic analysis.

Study Type : In Vitro Study

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