Selenium Supplementation and Prostate Health in a New Zealand Cohort.
Nutrients. 2019 Dec 18 ;12(1). Epub 2019 Dec 18. PMID: 31861307
BACKGROUND: There is variable reporting on the benefits of a 200μg/d selenium supplementation towards reducing prostate cancer impacts. The current analysis is to understand whether stratified groups receive supplementation benefits on prostate health.
METHODS: 572 men were supplemented with 200µg/d selenium as selinized yeast for six months, and 481 completed the protocol. Selenium and prostate-specific antigen (PSA) levels were measured in serum at pre- and post-supplementation. Changes in selenium and PSA levels subsequent to supplementation were assessed with and without demographic,lifestyle, genetic and dietary stratifications.
RESULTS: The post-supplementation selenium (= 0.002) and the gain in selenium (<0.0001) by supplementation were significantly dependent on the baseline selenium level. Overall, there was no significant correlation between changes in PSA and changes in selenium levels by supplementation. However, stratified analyses showed a significant inverse correlation between changes in PSA and changes in selenium in men below the median age (= 0.048), never-smokers (= 0.031), men carrying the GPX1 rs1050450 T allele (CT,= 0.022 and TT,= 0.011), dietary intakes above the recommended daily intake (RDI) for zinc (<0.05), and below the RDI for vitamin B12 (<0.001).
CONCLUSIONS: The current analysis shows the influence of life factors on prostate health benefits of supplemental selenium.