n/a
Abstract Title:

Identification of ginkgolide targets in brain by photoaffinity-labeling.

Abstract Source:

Chem Biol Drug Des. 2016 Oct 15. Epub 2016 Aug 15. PMID: 27743504

Abstract Author(s):

Akira Kawamura, Ilyas Washington, Doina M Mihai, Francesca Bartolini, Gregg G Gundersen, Milica Tesic Mark, Koji Nakanishi

Article Affiliation:

Akira Kawamura

Abstract:

Ginkgolides are terpene trilactones in Ginkgo biloba, a popular medicinal herb for memory disorders. Although ginkgolides are known for various neurobiological effects, their macromolecular target in brain is unknown. In this work, we employed benzophenone derivatives of ginkgolides to identify their binding-target in brain. Photolabeling of bovine hippocampus homogenates identified a series ofα-tubulin isotypes. Selective photolabeling of α-tubulin over β-tubulin, which is equally abundant in brain, suggested that ginkgolides might modulate microtubule (MT) biology differently than typical MT-binding agents, such as taxol. In fact, ginkgolide A did not affect MT polymerization or cellproliferation; instead, it inhibited detyrosination of α-tubulin and reorientation of microtubule-organizing centers (MTOCs). Taken together, the current findings indicate that ginkgolides constitute a new class of MT-binding agents with distinct effects on α-tubulin biology. This article is protected by copyright. All rights reserved.

Study Type : Commentary
Additional Links

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.