anxiolytic andanti-inflammatory activities of water-soluble extract (WSE) of(L.) seeds.
Nat Prod Res. 2019 Oct 3:1-6. Epub 2019 Oct 3. PMID: 31578877
Z M Babar
The WSE is a highly polar, gummy and mucilaginous bioactive content of the(L.) seeds. This study reports the anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and protein denaturation respectively. The oral WSE treatment (100&200 mg/kg b.w/day) for 72 hours has exhibited slightly better anxiolytic effect ( < 0.05) through the time span (92.33&93.33 s) spent in the opened arms of EPM. diazepam (1 mg/kg b.w i.p/day; 69.33 s). In HBT, only WSE (200 mg/kg b.w/day) has shown a promising number of mean head pokes (13.27 times/min). diazepam (12.87 times/min). The WSE (62.5-500 µg/mL) exposure has exhibited 40.14-72.18% protection against lysis of RBCs. aspirin (57.04-71.48%) whilst 62.67-67.66% inhibition of protein denaturation. diclofenac sodium (43.11-80.64%). The current findings suggested WSE has promising anxiolytic and anti-inflammatory activities.