Article Publish Status: FREE
Abstract Title:

Current status on marine products with reversal effect on cancer multidrug resistance.

Abstract Source:

Mar Drugs. 2012 Oct ;10(10):2312-21. Epub 2012 Oct 19. PMID: 23170086

Abstract Author(s):

Ioana Abraham, Khalid El Sayed, Zhe-Sheng Chen, Huiqin Guo

Article Affiliation:

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, NY 11439, USA; Email: ioana.abraham@yahoo.com.

Abstract:

The resistance of tumor cells to a broad range of anticancer agents continues to be a problem for the success of cancer chemotherapy. Multidrug resistance (MDR) is due in part to three drug transporter proteins: ABCB1/P-glycoprotein (P-gp), ABCC1/multidrug resistance protein 1 (MRP1) and ABCG2/breast cancer resistance protein (BCRP). These transporters are part of the ATP-binding cassette (ABC) superfamily, whose members function as ATP-dependent drug-efflux pumps. Their activity can be blocked by various drugs such as verapamil (calcium channel blocker) and cyclosporin A (immunosuppressive agent), etc. These compounds are called MDR modulators or reversals. This review highlights several marine natural products with reversal effect on multidrug resistance in cancer, including agosterol A, ecteinascidin 743, sipholane triterpenoids, bryostatin 1, and welwitindolinones.

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