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Abstract Title:

[Effect of C21 steroidal glycoside from root of Cynanchum auriculatum on D-galactose induced aging model mice].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2007 Dec;32(23):2511-4. PMID: 18330246

Abstract Author(s):

Shi-Xia Zhang, Xin Li, Jia-Le Yin, Li-Li Chen, Hong-Quan Zhang

Article Affiliation:

The Medical and Pharmaceutical Academy of Yangzhou University, Yangzhou 225001, China.

Abstract:

OBJECTIVE: To study the effect of C21 steroidal glycoside (CSG) from the root of Cynanchum auriculatum from Jiangsu on D-galactose (D-gal) induced aging model mice.

METHOD: D-gal aging mouse model was established by cervicodorsal region subcutaneous injection with D-gal once a day for eight successive weeks. The mice in the normal control group (NCG, non-modeled) and the model control group (MCG, modeled but untreated) were treated with 1% CMC-Na. The model mice in the low, middle and high-dose CSG and Vitamin E treated groups were treated with a dose of (10, 20, 40, 100 mg x kg(-1) per day, respectively. The SOD activity, MDA content and telomerase activity in serum, heart, liver and brain tissues of mice were measured.

RESULT: CSG could obviously increase the SOD activity and decrease the MDA level in serum, heart, liver and brain tissues in D-gal aging mice (P<0.01). There was no significant difference between three CSG treated groups and Vitamin E treated groups. In comparison of telomerase activity between MCG and the treated groups, it was shown that there was a significant increase in serum in middle and high dose group, and in heart tissues in CSG and Vit E treated groups, but was not in liver and brain tissue.

CONCLUSION: This study demonstrates that CSG can antagonize free radical injury, increase the SOD activity and decrease the MDA content of serum, heart, liver and brain in D-gal aging mice, and increase the telomerase activity in serum and heart tissues but not in liver and brain tissue.

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Sayer Ji
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