Article Publish Status: FREE
Abstract Title:

Cytotoxic effect ofkernel extract on HCT116 and A2058 cancer cell lines.

Abstract Source:

Heliyon. 2020 Sep ;6(9):e04941. Epub 2020 Sep 19. PMID: 33005784

Abstract Author(s):

Yana Feodorova, Teodora Tomova, Danail Minchev, Valentin Turiyski, Marian Draganov, Mariana Argirova

Article Affiliation:

Yana Feodorova


While the pharmacology ofleaf extract has been studied extensively, little is known about the pharmacological potential ofseeds, although they contain similar active ingredients that are responsible for the therapeutic effects of the leaf extract. In this study we used 70%-methanolkernel extract, quantified its bioactive constituents and tested their cytotoxic effect on two cancer cell lines, A2058 and HCT116, and the non-tumor cell line McCoy-Plovdiv. We studied the biological effect of the extract by real-time analysis in the xCELLigence system, WST-1 assay and LIVE/DEAD viability assay. We show that the extract significantly perturbed the viability of cancer cells in a concentration- and time-dependent manner. In contrast, non-cancerous McCoy-Plovdiv cells sustained their proliferation potential even at high concentrations of the extract. Therefore, we propose that the active constituents of theendosperm extract may interact additively or synergistically to protect against cancer.

Study Type : In Vitro Study

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