Article Publish Status: FREE
Abstract Title:

Biochemical and histopathological effects of catechin on experimental peripheral nerve injuries.

Abstract Source:

Turk Neurosurg. 2015 ;25(3):453-60. PMID: 26037187

Abstract Author(s):

Ali Erdem Yildirim, Ali Dalgic, Denizhan Divanlioglu, Rifat Akdag, Nuri Eralp Cetinalp, Fatih Alagoz, Fatma Helvacioglu, Gulnur Take, Yahya Guvenc, Ismet Koksal, Ahmed Deniz Belen

Article Affiliation:

Ali Erdem Yildirim

Abstract:

AIM: Catechin is a type of polyphenol, along with epicatechin, epigallocatechin, and epigallocatechin-gallate (EGCG). This study aims to investigate the effect of EGCG, a major metabolite of catechin, which is the principle bioactive compound in green tea, on rats with peripheral nerve injury.

MATERIAL AND METHODS: A total of 74 rats were divided into six groups, namely the control, the trauma, the normal saline, a 25mg/kg EGCG, a 50mg/kg EGCG and a daily consumption group (10mg/kg EGCG was given intraperitoneally for 14 days before the trauma). Except the first group, the other groups underwent a 1-minute sciatic nerve compression by clip with 50gr/cm2 pressure. Nerve samples were obtained at 28 day after trauma for the biochemical and histopathological analysis.

RESULTS: Our study showed that the Daily consumption, 25mg/kg EGCG and 50mg/kg EGCG groups demonstrated statistically significant decreased lipid peroxidation levels and particularly daily consumption, and the 25mg/kg EGCG group showed a favourable reduction of degeneration and edema histologically.

CONCLUSION: This study shows that Catechin and its derivatives have a protective effect on peripheral nerve injury.

Study Type : Animal Study

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