Abstract Title:

The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day.

Abstract Source:

J Altern Complement Med. 2009 Aug;15(8):929-34. PMID: 19678785

Abstract Author(s):

Bevin A Clare, Richard S Conroy, Kevin Spelman

Abstract:

BACKGROUND: Taraxacum officinale (L.) Weber (Asteraceae) has been extensively employed as a diuretic in traditional folk medicine and in modern phytotherapy in Europe, Asia, and the Americas without prior clinical trial substantiation. OBJECTIVES: In this pilot study, a high-quality fresh leaf hydroethanolic extract of the medicinal plant T. officinale (dandelion) was ingested by volunteers to investigate whether an increased urinary frequency and volume would result. DESIGN: Volume of urinary output and fluid intake were recorded by subjects. Baseline values for urinary frequency and excretion ratio (urination volume:fluid intake) were established 2 days prior to dandelion dosing (8 mL TID) and monitored throughout a 1-day dosing period and 24 hours postdosing. RESULTS: For the entire population (n = 17) there was a significant (p<0.05) increase in the frequency of urination in the 5-hour period after the first dose. There was also a significant (p<0.001) increase in the excretion ratio in the 5-hour period after the second dose of extract. The third dose failed to change any of the measured parameters. CONCLUSIONS: Based on these first human data, T. officinale ethanolic extract shows promise as a diuretic in humans. Further studies are needed to establish the value of this herb for induction of diuresis in human subjects.

Study Type : Human Study
Additional Links
Pharmacological Actions : Diuretics : CK(55) : AC(15)

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