Abstract Title:

Anti-carcinogenic activity of Taraxacum plant. I.

Abstract Source:

J Exp Ther Oncol. 2008;7(4):275-84. PMID: 10408234

Abstract Author(s):

M Takasaki, T Konoshima, H Tokuda, K Masuda, Y Arai, K Shiojima, H Ageta

Article Affiliation:

Kyoto Pharmaceutical University, Japan.


An extract of the roots of Taraxacum japonicum (Compositae) exhibited strong anti-tumor-promoting activities on the two-stage carcinogenesis of mouse skin tumor induced by dimethylbenz[a] anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter, as well as on that induced by DMBA and fumonisin B1. Further, the extract exhibited anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexen amide (NOR-1) as an initiator and TPA as a promoter. These results suggested that an extract of the roots of the Taraxacum plant could be a valuable chemopreventive agent against chemical carcinogenesis.

Study Type : Animal Study

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