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Abstract Title:

Parental perinatal exposure to bisphenol A reduces the threshold to disrupt blastocyst implantation via decreasing talin, occudin and E-cadherin levels.

Abstract Source:

Reprod Toxicol. 2019 Apr 24. Epub 2019 Apr 24. PMID: 31028817

Abstract Author(s):

Annia A Martínez-Peña, Andrea Peña-Castillo, L Yuliana Parra-Forero, Isabel Hernández-Ochoa, Luis R Hernández-Barrientos, Sumiko Morimoto, C Adriana Mendoza Rodríguez

Article Affiliation:

Annia A Martínez-Peña

Abstract:

The aim was to evaluate the effect of perinatal BPA exposure of one or both parents on the implantation index and expression of talin, occludin and E-cadherin in the uterine epithelial cells (UEC) of the offspring. Pregnant Wistar dams (F0) received BPA or vehicle from gestational day (GD) 6 to lactation day 21. F1 animals were mated forming four groups: Control dam-Control sire (C♀-C♂), BPA dam -Control sire (B♀-C♂), Control dam -BPA sire (C♀-B♂), BPA dam -BPA sire (B♀-B♂). F1 dams were sacrificed at GD 6. Significantly decreased number of implantation sites was observed in the B♀-B♂ group as compared to the C♀-C♂ group, which correlated with decreased talin apical/basal expression ratio, occludin apical expression, and E-cadherin apical/lateral expression ratio in the UEC. Furthermore, decreased E-cadherin expression in the blastocyst was observed. Our data suggest that reduced protein expressions in F1 BPA offspring could result from decreasedprogesterone serum levels.

Study Type : Animal Study

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