Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.
Clin Pharmacol Ther. 2007 May ;81(5):650-3. Epub 2007 Feb 28. PMID: 17329991
Department of Pathology&Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, and Research Unit, Tampere University Hospital, Finland.
Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.