Article Publish Status: FREE
Abstract Title:

Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro.

Abstract Source:

Int J Mol Med. 2018 Jun ;41(6):3157-3166. Epub 2018 Mar 5. PMID: 29512685

Abstract Author(s):

Wen Kang, Xiao Zheng, Ping Wang, Shanyu Guo

Article Affiliation:

Wen Kang


During the pathogenesis of gastric cancer, Akt signaling is considered as a pivotal inducer of gastric cancer development. Here we report the identification of anticancer activities of deguelin, a natural agent that inhibits Akt signaling. When applied to MGC-803 and MKN-45 cells, deguelin suppressed the proliferation and arrested cell cycle by p21-mediated inhibition of cyclin E. We further present in vitro evidence that deguelin promoted apoptosis of cancer cells by decreasing the phospho-Akt signaling and affecting expression of the apoptosis-associated genes Bax and Bcl-2. Additionally, deguelin was found to suppress the migration and invasion of gastric cancer cells. Taken together, these results indicated that deguelin exerted anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro.

Study Type : In Vitro Study

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