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Article Publish Status: FREE
Abstract Title:

Deguelin inhibits proliferation and migration of human pancreatic cancer cellstargeting hedgehog pathway.

Abstract Source:

Oncol Lett. 2016 Oct ;12(4):2761-2765. Epub 2016 Aug 2. PMID: 27698853

Abstract Author(s):

Wen Zheng, Shiliu Lu, Haolei Cai, Muxing Kang, Wenjie Qin, Chao Li, Yulian Wu

Article Affiliation:

Wen Zheng

Abstract:

Pancreatic cancer (PC) is a highly lethal malignancy with few effective therapies. Deguelin, a natural compound of the flavonoid family of products, has been reported to have an inhibitory effect on various cancers. In the present study, we investigated whether deguelin had antitumor efficacy in PC. Deguelin treatment was observed to inhibit growth and induce apoptosis in two PC cell lines (Bxpc-3 and Panc-1). In addition, it inhibited migration and invasion in these two cell lines. The activation of the hedgehog (Hh) signaling pathway, as well as matrix metalloproteinases (MMP)-2 and MMP-9, was suppressed by deguelin. These results suggest that deguelin may be a potential chemotherapeutic agent for PC, possibly through the suppression of the Hh signaling pathway.

Study Type : In Vitro Study

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