Delayed focal lipoatrophy after AS03-adjuvanted influenza A (H1N1) 2009 vaccine.
Vaccine. 2010 Dec 17. Epub 2010 Dec 17. PMID: 21172376
Department of Infectious Diseases and Tropical Medicine, Laveran Military Teaching Hospital, 4, Boulevard Laveran, BP 60149, 13 384 Marseille Cedex 13, France.
Intramuscular vaccination may lead to loss of subcutaneous fat resulting in skin depression at the site of injection. We report for the first time a delayed lipoatrophy after with AS03-adjuvanted influenza A (H1N1) 2009 vaccine. Inadequate administration into the adipose tissue may be causative. During next pandemic, education to optimal intramuscular administration and prolonged monitoring of adverse effects could be proposed.