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Abstract Title:

Delphinidin-induced autophagy protects pancreaticβ cells against apoptosis resulting from high-glucose stress via AMPK signaling pathway.

Abstract Source:

Acta Biochim Biophys Sin (Shanghai). 2019 Dec 13 ;51(12):1242-1249. PMID: 31781740

Abstract Author(s):

Dengni Lai, Mingyong Huang, Lingyan Zhao, Yan Tian, Yong Li, Dongpo Liu, Yanyang Wu, Fangming Deng

Article Affiliation:

Dengni Lai

Abstract:

Hyperglycemia, a diagnostic characteristic of diabetes mellitus, is detrimental to pancreaticβ cells. Delphinidin, a member of the anthocyanin family, inhibits glucose absorption, increases glucagon-like peptide-1 (GLP-1) secretion, and improves insulin secretion in diabetes. However, whether delphinidin plays a protective role in pancreatic β-cell mass and function is not clear. In thisstudy, delphinidin was found to decrease the high-glucose-induced apoptosis of RIN-m5F pancreatic β cells. In addition, delphinidin induced autophagy in RIN-m5F cells under the normal and high-glucose conditions, while 3-methyladenine (3-MA) inhibition of autophagy significantly diminished the protective role of delphinidin against high-glucose-induced apoptosis of pancreatic β cells. Delphinidin also decreased the level of cleaved caspase 3 and increased the phosphorylation level of AMP-activated protein kinase α (AMPKα) Thr172. Compound C, an AMPK inhibitor, was found to decrease the ratio of LC3-II/LC3-I, and the apoptotic rate of high-glucose-injured cells was increased after treatment with delphinidin, indicating that delphinidin attenuated the negative effects of high-glucose stress to cells. In conclusion, our data demonstrate that delphinidin protects pancreatic β cells against high-glucose-induced injury by autophagy regulation via the AMPK signaling pathway. These findings might shed light on the underlying mechanisms of diabetes and help improve the prevention and therapy of this common disease.

Study Type : In Vitro Study

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