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Abstract Title:

Delphinidin Prevents Muscle Atrophy and Upregulates miR-23a Expression.

Abstract Source:

J Agric Food Chem. 2017 Jan 11 ;65(1):45-50. Epub 2016 Dec 29. PMID: 28000445

Abstract Author(s):

Motoki Murata, Haruna Nonaka, Satomi Komatsu, Megumi Goto, Mai Morozumi, Shuhei Yamada, I-Chian Lin, Shuya Yamashita, Hirofumi Tachibana

Article Affiliation:

Motoki Murata

Abstract:

Delphinidin, one of the major anthocyanidins, shows protective effects against a variety of pathologies, including cancer, inflammation, and muscle atrophy. The purpose of this study was to determine the preventive mechanism of delphinidin on disuse muscle atrophy. In vitro and in vivo models were used to validate the effects of delphinidin on the expression of MuRF1, miR-23a, and NFATc3. Delphinidin suppressed the upregulation of MuRF1 (1.77± 0.05 vs 1.03 ± 0.17, P<0.05) expression and inhibited the downregulation of miR-23a (0.56± 0.05 vs 0.94 ± 0.06, P<0.05) and NFATc3 (0.61± 0.02 vs 1.02 ± 0.08, P<0.01) expression in dexamethasone-treated C2C12 cells. In gastrocnemius, muscle weight loss was prevented by oral administration of delphinidin. Moreover, delphinidin suppressed MuRF1 (3.35± 0.13 vs 2.26 ± 0.3, P<0.01) expression and promoted miR-23a (0.58± 0.15 vs 2.25 ± 0.29, P<0.001) and NFATc3 (0.85± 0.17 vs 1.54 ± 0.13, P<0.001) expressions. Delphinidin intake may prevent disuse muscle atrophy by inducing miR-23a expression and suppressing MuRF1 expression.

Study Type : Animal Study, In Vitro Study

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