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Article Publish Status: FREE
Abstract Title:

Cytotoxic effects of delphinidin in human osteosarcoma cells.

Abstract Source:

Acta Orthop Traumatol Turc. 2017 Dec 28. Epub 2017 Dec 28. PMID: 29290536

Abstract Author(s):

Dong-Yeong Lee, Young-Jin Park, Sun-Chul Hwang, Kwang-Dong Kim, Dong-Kyu Moon, Dong-Hee Kim

Article Affiliation:

Dong-Yeong Lee

Abstract:

INTRODUCTION: The aim of this study was to evaluate whether delphinidin is cytoprotective or cytotoxic in osteosarcoma cell lines, and to elucidate the underlying mechanisms.

MATERIALS AND METHODS: The present study investigated whether apoptosis or autophagy is induced by delphinidin in human osteosarcoma cell lines. Delphinidin was used as the antioxidant, along with two autophagy inhibitors: 3-methyladenine and bafilomycin A1. Cell viability and known autophagic markers, such as LC3-II expression, were evaluated. Reactive oxygen species (ROS) formation and cell cycle analysis were also investigated.

RESULTS: Delphinidin showed concentration-dependent cytotoxicity to osteosarcoma cell. Delphinidin is closely associated with apoptotic cell death mechanisms and pathways related to ROS accumulation. In addition, we observed delphinidin-induced autophagosome formation and increasing levels of LC3-II conversion. However, in spite of delphinidin induced autophagy, the cytotoxic effects induced in the osteosarcoma cells may not be operating via autophagic cell death mechanisms.

CONCLUSIONS: Delphinidin compromises the cellular protective mechanisms by inhibiting autophagy, permitting ROS to accumulate and finally enhance apoptotic cell death. Our results indicate that delphinidin may play a critical role as a chemotherapeutic agent by preventing the development and progression of osteosarcoma cells.

Study Type : In Vitro Study

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