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Abstract Title:

Delta9-tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro.

Abstract Source:

J Neuroimmunol. 2009 Feb 15 ;207(1-2):75-82. Epub 2009 Jan 22. PMID: 19167098

Abstract Author(s):

Marcel Jenny, Elisabeth Santer, Eberhard Pirich, Harald Schennach, Dietmar Fuchs

Article Affiliation:

Marcel Jenny

Abstract:

Nanomolar concentrations of Delta9-tetrahydrocannabinol or cannabidiol are demonstrated to enhance mitogen-induced degradation of tryptophan in human peripheral blood mononuclear cells in dependence of CB1- or CB2-receptor activation. In contrast, suppression of this pathway by cannabinoids in the micromolar concentration range was achieved independent of cannabinoid receptor activation. Both cannabinoids also suppressed tryptophan degradation in myelomonocytic THP-1 cells stimulated with lipopolysaccharide. We conclude, that suppression of tryptophan degradation by cannabinoids via indoleamine-2,3-dioxygenase, which is independent of cannabinoid receptor activation, might enhance the availability of tryptophan for serotonin biosynthesis and consequently can be important in the action of cannabinoids to improve mood disturbances.

Study Type : In Vitro Study

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