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Abstract Title:

Developmental programming: Sex-specific programming of growth upon prenatal bisphenol A exposure.

Abstract Source:

J Appl Toxicol. 2019 Jul 23. Epub 2019 Jul 23. PMID: 31338854

Abstract Author(s):

Arpita Kalla Vyas, Almudena Veiga-Lopez, Wen Ye, Bachir Abi Salloum, David H Abbott, Shengping Yang, Chunyang Liao, Kurunthachalam Kannan, Vasantha Padmanabhan

Article Affiliation:

Arpita Kalla Vyas

Abstract:

In both human and animals, in utero exposure to bisphenol A (BPA), an endocrine-disrupting chemical used in the production of plastics and epoxy resins, has been shown to affect offspring reproductive and metabolic health during adult life. We hypothesized that the effect of prenatal exposure to environmentally relevant doses of BPA will be evident during fetal organogenesis and fetal/postnatal growth trajectory. Pregnant ewes were administered BPA subcutaneously from 30 to 90 days of gestation (term 147 days). Fetal organ weight, anthropometric measures, maternal/fetal hormones and postnatal growth trajectory were measured in both sexes. Gestational BPA administration resulted in higher accumulation in male than female fetuses only at fetal day 65, with minimal impacton fetal/maternal steroid milieu in both sexes at both time points. BPA-treated male fetuses were heavier than BPA-treated female fetuses at fetal day 90 whereas this sex difference was not evident in the control group. At the organ level, liver weight was reduced in prenatal BPA-treated female fetuses, while heart and thyroid gland weights were increased in BPA-treated male fetuses relative to their sex-matched control groups. Prenatal BPA treatment also altered the postnatal growth trajectory in a sex-specific manner. Males grew slower during the early postnatal period and caught up later.Females, in contrast, demonstrated the opposite growth trend. Prenatal BPA-induced changes in fetal organ differentiation and early life growth strongly implicate translational relevance of in utero contributions to reproductive and metabolic defects previously reported in adult female offspring.

Study Type : Animal Study

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