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Abstract Title:

Dibenzocyclooctadiene lignans from the fruits of Schisandra rubriflora and their anti-HIV-1 activities.

Abstract Source:

J Asian Nat Prod Res. 2011 May ;13(5):393-9. PMID: 21534036

Abstract Author(s):

Huai-Xue Mu, Xue-Sen Li, Peng Fan, Guang-Yu Yang, Jian-Xin Pu, Han-Dong Sun, Qiu-Fen Hu, Wei-Lie Xiao

Article Affiliation:

Huai-Xue Mu

Abstract:

Two new dibenzocyclooctadiene lignans, rubrilignans A and B (1, 2), together with 17 known ones, were isolated from the fruits of Schisandra rubriflora. The structures of 1 and 2 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were also evaluated for their anti-HIV-1 activities and showed weak anti-HIV-1 activity with EC(50) values of 2.26 and 1.82μg/ml, and therapeutic index values of 35.5 and 18.6, respectively.

Study Type : In Vitro Study

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