Article Publish Status: FREE
Abstract Title:

Didymin improves UV irradiation resistance in.

Abstract Source:

PeerJ. 2019 ;6:e6218. Epub 2019 Jan 9. PMID: 30643686

Abstract Author(s):

Lin Zhou, Lu Wang, Jialing Zhang, Jiahe Li, Shuju Bai, Junfeng Ma, Xueqi Fu

Article Affiliation:

Lin Zhou


Didymin, a type of flavono-o-glycoside compound naturally present in citrus fruits, has been reported to be an effective anticancer agent. However, its effects on stress resistance are unclear. In this study, we treatedwith didymin at several concentrations. We found that didymin reduced the effects of UV stressor on nematodes by decreasing reactive oxygen species levels and increasing superoxide dismutase (SOD) activity. Furthermore, we found that specific didymin-treated mutant nematodes(mu86)&(e1370),(mu86),(ok525),(ok393), and(hx546) were susceptible to UV irradiation, whereas(e1371) was resistant to UV irradiation. In addition, we found that didymin not only promoted DAF-16 to transfer from cytoplasm to nucleus, but also increased both protein and mRNA expression levels of SOD-3 and HSP-16.2 after UV irradiation. Our results show that didymin affects UV irradiation resistance and it may act onto regulate downstream genes through the insulin/IGF-1-like signaling pathway.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.