Didymin improves UV irradiation resistance in C. elegans. - GreenMedInfo Summary
Didymin improves UV irradiation resistance in.
PeerJ. 2019 ;6:e6218. Epub 2019 Jan 9. PMID: 30643686
Didymin, a type of flavono-o-glycoside compound naturally present in citrus fruits, has been reported to be an effective anticancer agent. However, its effects on stress resistance are unclear. In this study, we treatedwith didymin at several concentrations. We found that didymin reduced the effects of UV stressor on nematodes by decreasing reactive oxygen species levels and increasing superoxide dismutase (SOD) activity. Furthermore, we found that specific didymin-treated mutant nematodes(mu86)&(e1370),(mu86),(ok525),(ok393), and(hx546) were susceptible to UV irradiation, whereas(e1371) was resistant to UV irradiation. In addition, we found that didymin not only promoted DAF-16 to transfer from cytoplasm to nucleus, but also increased both protein and mRNA expression levels of SOD-3 and HSP-16.2 after UV irradiation. Our results show that didymin affects UV irradiation resistance and it may act onto regulate downstream genes through the insulin/IGF-1-like signaling pathway.