Abstract Title:

Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity.

Abstract Source:

J Med Food. 2015 Oct 27. Epub 2015 Oct 27. PMID: 26505950

Abstract Author(s):

Soo Jung Choi, Seung Sang Oh, Cho Rong Kim, Yoon Kyung Kwon, Soo Hwan Suh, Jae Kyeom Kim, Gwi Gun Park, Seung-Yeol Son, Dong-Hoon Shin

Article Affiliation:

Soo Jung Choi


One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performed to examine the effects of the P. frutescens extract on trimethyltin chloride-induced impairment of learning and memory in mice. A diet containing P. frutescens extract effectively reversed learning and memory impairment on the Y-maze and passive avoidance tests. To isolate the active compound from the P. frutescens extract, solvent partitioning, silica gel open column chromatography, thin-layer chromatography, and high-performance liquid chromatography were used. The AChE inhibitor was identified as rosmarinic acid.

Study Type : Animal Study

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