Dietary apigenin in the prevention of endothelial cell dysfunction. - GreenMedInfo Summary
Dietary apigenin in the prevention of endothelial cell dysfunction.
J Cardiovasc Pharmacol. 2019 Oct 7. Epub 2019 Oct 7. PMID: 31517778
Ned J Lamb
The anti-carcinogenic effects of the polyphenol apigenin (4', 5, 7-trihydroxyflavone) have been amply documented and are currently assessed in clinical studies. Potential benefits against other inflammatory diseases, such as atherosclerosis, are also being uncovered. Following their previous work in the field, Yamagata et al., report in the present issue that"Dietary apigenin reduces induction of LOX-1 and NLRP3 expression, leukocyte adhesion and acetylated low density lipoprotein uptake in human endothelial cells exposed to trimethylamine-N-oxide". Here, the context of this molecular study and its potential for future breakthroughs in cardiovascular pharmacology are discussed.