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Article Publish Status: FREE
Abstract Title:

Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.

Abstract Source:

Nutrients. 2020 06 26 ;12(6). Epub 2020 Jun 26. PMID: 32604971

Abstract Author(s):

Hamid A Bakshi, Mazhar S Al Zoubi, Faruck L Hakkim, Alaa A A Aljabali, Firas A Rabi, Amin A Hafiz, Khalid M Al-Batanyeh, Bahaa Al-Trad, Prawej Ansari, Mohamed M Nasef, Nitin B Charbe, Saurabh Satija, Meenu Mehta, Vijay Mishra, Gaurav Gupta, Salem Abobaker, Poonam Negi, Ibrahim M Azzouz, Ashref Ali K Dardouri, Harish Dureja, Parteek Prasher, Dinesh K Chellappan, Kamal Dua, Mateus Webba da Silva, Mohamed El Tanani, Paul A McCarron, Murtaza M Tambuwala

Article Affiliation:

Hamid A Bakshi

Abstract:

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

Study Type : Animal Study

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