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Article Publish Status: FREE
Abstract Title:

Dietary exposure to brominated flame retardants and abnormal Pap test results.

Abstract Source:

J Womens Health (Larchmt). 2011 Sep ;20(9):1269-78. Epub 2011 Jul 28. PMID: 21797757

Abstract Author(s):

Denise J Jamieson, Metrecia L Terrell, Nnenna N Aguocha, Chanley M Small, Lorraine L Cameron, Michele Marcus

Article Affiliation:

Denise J Jamieson

Abstract:

OBJECTIVE: This study examined a possible association of dietary exposure to polybrominated biphenyls (PBBs), a brominated flame retardant, and self-reported abnormal Pap test results and cervical dysplasia as a precursor to cervical cancer.

METHODS: Women in Michigan who ingested contaminated poultry, beef, and dairy products in the early 1970s were enrolled in a population-based cohort study in Michigan. Serum PBB and serum polychlorinated biphenyl (PCB) concentrations were measured. Reproductive history and health information, including Pap test results, were self-reported by participants.

RESULTS: Of the women, 23% (223 of 956) reported an abnormal Pap test. In unadjusted analyses, self-reporting an abnormal Pap test was associated with younger age, current smoking (hazard ratio [HR] 1.61, 95% confidence interval [CI] 1.19-2.17), and longer duration of lifetime use of oral contraceptives (≥10 years; HR 1.92, 95% CI 1.21-3.06). When adjusting for PCB exposure, age at the interview, and smoking history, there was a slightly elevated risk of self-reporting an abnormal Pap test among the highly exposed women compared to women with nondetectable PBB concentrations (PBB≥13 μg/L, HR1.23, 95% CI 0.74-2.06); however, the CI was imprecise. When breastfeeding duration after the initial PBB measurement was taken into account, there was a reduced risk of self-reporting an abnormal Pap test among the highly exposed women who breastfed for ≥12 months (HR 0.41, 95% CI 0.06-3.03; referent group: women with nondetectable PBB concentrations who did not breastfeed).

CONCLUSIONS: It remains important to evaluate the potential reproductive health consequences of this class of chemicals as well as other potential predictors of abnormal Pap tests.

Study Type : Human Study
Additional Links
Therapeutic Actions : Breastfeeding : CK(803) : AC(85)

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Sayer Ji
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