Abstract Title:

Dietary grape seed procyanidin extract protects against lead-induced heart injury in rats involving endoplasmic reticulum stress inhibition and AKT activation.

Abstract Source:

J Nutr Biochem. 2018 Dec ;62:43-49. Epub 2018 Aug 14. PMID: 30245182

Abstract Author(s):

Daqian Yang, Siyu Li, Li Gao, Zhanjun Lv, Qizheng Bing, Qingjie Lv, Xiaoyan Zheng, Ruobing Li, Zhigang Zhang

Article Affiliation:

Daqian Yang


To investigate the protective role of grape seed procyanidin extract (GSPE) against lead-induced heart injury and the possible molecular mechanism associated with this event, Wistar rats were orally given GSPE (200 mg/kg) daily with or without lead acetate (PbA) (0.5 g/L) in drinking water for 56 d. GSPE attenuated oxidative stress, heart dysfunction, and lead accumulation in lead-exposed rat hearts. Meanwhile, GSPE inhibited the protein kinase RNA-like endoplasmic reticulum (ER) kinase/eukaryotic initiation factor 2α signaling pathway, and promoted protein kinase B (AKT) and glycogen synthase kinase 3β phosphorylation altered by lead, and regulated lead-activated apoptosis and its related signaling pathway. This study suggests that dietary GSPE ameliorates lead-induced heart injury associated with ER stressinhibition and AKT activation. Dietary GSPE may be a protector against lead-induced heart injury and a novel therapy for lead exposure.

Study Type : Animal Study

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