Antiobesity Effects ofLMT1-48 Accompanied by Inhibition ofin the Intestine of Diet-Induced Obese Mice.
J Med Food. 2019 Apr 23. Epub 2019 Apr 23. PMID: 31013456
Woo Jin Choi
The gut microbiota is the most important environmental factor that plays a role in inducing obesity. The gram-negative bacteria,strains, recently identified in obese mice are considered to be pathogenic bacteria in the gut. Probiotics are important members of the gut microbiota and exert beneficial effects, including inhibiting the growth of potential pathogenic bacteria. Therefore, we isolated a total of 230 lactic acid bacteria from traditional, Korean fermented foods and fecal samples from newborn infants, includingLMT1-48, which exhibited maximal antimicrobial activity againstWe next investigated the functional antiobesity effects ofLMT1-48 in an-induced high-fat diet (HFD)-fed animal obesity model. To this end, theLMT1-48 showed antiobesity effects, including body weight loss and reduction of abdominal fat volume, which was accompanied by a decrease in leptin and total cholesterol levels in-induced HFD-fed mice. Notably, gut microbiota diversity also increased after long-term ingestion ofLMT1-48, resulting in amelioration of obesity in-induced HFD-fed mice. Accordingly, results suggest that dietary intake ofLMT1-48 protects against the onset of-induced obesity.