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Abstract Title:

Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice.

Abstract Source:

Dig Dis Sci. 2012 Feb ;57(2):355-63. Epub 2011 Sep 8. PMID: 21901258

Abstract Author(s):

Mi-Young Park, Geun Eog Ji, Mi-Kyung Sung

Article Affiliation:

Mi-Young Park

Abstract:

BACKGROUND: In ulcerative colitis (UC), reduction of inflammation may represent a key mechanism in UC therapy, and anti-inflammatory agents would be good candidates for preventing UC. Kaempferol, a natural flavonoid, is believed to have anti-inflammatory activities and has been shown to be potentially immune-modulatory.

AIMS: The aim of this study was to determine whether kaempferol alleviates the inflammatory responses of dextran sulfate sodium (DSS)-induced colitis in mice.

METHODS: Female C57BL/6J mice were divided into six groups: a negative control group, a DSS control group, and DSS + 0.1% or 0.3% kaempferol pre- or post-fed groups. At the end of the experimental period, clinical and biochemical markers were evaluated.

RESULTS: Plasma levels of NO and PGE(2) were significantly decreased in both the 0.3% kaempferol pre- and post-fed groups. The plasma LTB(4) level was profoundly decreased in all animals fed kaempferol. Colonic mucosa MPO activity was also suppressed in both the 0.3% kaempferol pre- or post-fed groups. TFF3 mRNA, a marker for goblet cell function, was up-regulated in kaempferol pre-fed animals.

CONCLUSIONS: These results indicate that kaempferol is an effective anti-inflammatory agent that protects colonic mucosa from DSS-induced UC. Dietary kaempferol fed prior to colitis induction was more effective to suppress some of the colitis-associated markers.

Study Type : Animal Study

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