Abstract Title:

Dietaryω3 fatty acids modulate the substrate for post-operative atrial fibrillation in a canine cardiac surgery model.

Abstract Source:

Cardiovasc Res. 2011 Mar 1;89(4):852-61. Epub 2010 Nov 30. PMID: 21123218

Abstract Author(s):

Fadia Mayyas, Seiichiro Sakurai, Rashmi Ram, Julie H Rennison, Eui-Seock Hwang, Laurie Castel, Beth Lovano, Marie-Luise Brennan, Douglas Bibus, Bill Lands, John Barnard, Mina K Chung, David R Van Wagoner

Article Affiliation:

Department of Molecular Cardiology, NE-61 Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Abstract:

AIMS: Pre-treatment with dietaryω3 polyunsaturated fatty acids (ω3-PUFA) has been reported to reduce the incidence of new-onset atrial fibrillation (AF) following cardiac surgery. In a canine cardiac surgery model, we evaluated the impact of dietary ω3-PUFA on atrial electrophysiological properties, inflammatory markers, the atrial endothelin-1 (ET-1) system, and the expression and distribution of connexin 43.

METHODS AND RESULTS: Adult mongrel dogs received either normal chow (NC, n = 11) or chow supplemented with fish oil (FO, 0.6 gω3-PUFA/kg/day, n = 9) for 3 weeks before surgery. A left thoracotomy was performed, and the left atrial appendage (LAA) was excised. Atrial pacing/recording wires were placed, and the pericardium/chest was closed. The atrial ratio of ω6/ω3 lipids decreased from 15-20 in NC to 2-3 in FO. FO treatment lowered pre-surgical and stabilized post-surgical arachidonate levels. Peak neutrophil to lymphocyte ratio was lower and decayed faster in FO-treated animals. Extensive inflammatory cell infiltration was present in NC atria, but was reduced in FO-treated dogs. FO-treated animals had lower post-surgical atrial expression of inducible nitric oxide synthase (iNOS) and reduced plasma ET-1. Expression of ET-1 and inositol trisphosphate receptor type-2 proteins in the LAA was also reduced. FO treatment prolonged post-operative atrial effective refractory period, slowed heart rate, and enhancedheart rate variability. Importantly, AF (>30 s) was inducible in four of six NC dogs, but no FO dogs.

CONCLUSION: Dietary FO attenuated AF inducibility following cardiac surgery by modulating autonomic tone and heart rate. FO also reduced atrial inflammation, iNOS, and ET-1 expression.

Study Type : Animal Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.