Article Publish Status: FREE
Abstract Title:

Dietary supplementation of vitamin D prevents the development of western diet-induced metabolic, hepatic and cardiovascular abnormalities in rats.

Abstract Source:

United European Gastroenterol J. 2018 Aug ;6(7):1056-1064. Epub 2018 May 17. PMID: 30228894

Abstract Author(s):

Giovanna Mazzone, Carmine Morisco, Vincenzo Lembo, Giuseppe D'Argenio, Maria D'Armiento, Antonella Rossi, Carmine Del Giudice, Bruno Trimarco, Nicola Caporaso, Filomena Morisco

Article Affiliation:

Giovanna Mazzone


Background: The western diet high in fat and fructose may cause metabolic disorders and cardiovascular diseases.

Objective: To evaluate whether long-term daily vitamin Dsupplementation prevents hepatic steatosis and cardiovascular abnormalities and restores insulin sensitivity caused by fat diet in rats without vitamin D deficiency.

Methods: Three groups of rats were fed for 6 months with standard diet (SD), western diet (WD) or WD containing 23 IU/day/rat vitamin D, respectively. Tail-cuff systolic blood pressure (SBP)measurements in conscious rats and transthoracic echocardiography were performed in basal condition, and after 3 and 6 months of diet. Hepatic steatosis and myocardial fibrosis were assessed in liver and cardiac tissues using standard methods. Serum insulin and 25(OH)D3 concentrations were determined using rat-specific ELISA kits. Insulin resistance was determined according to the homeostasis model assessment of insulin resistance (HOMA-IR) method.

Results: Sixty-one per cent of hepatocytes in WD rats had steatotic vacuoles compared with just 27% in rats on a WD plus vitamin D( < 0.05).HOMA-IR was reduced in rats with vitamin D supplementation compared with WD alone (19.4 ± 5.2 vs 41.9 ± 8.9, < 0.05). Rat blood pressure and left ventricular mass were both reduced by vitamin Dsupplementation.

Conclusion: In animal models of liver and cardiovascular metabolic damage, the supplementation of vitamin Dshows liver and cardio-protective effects.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.