A Dihydroflavonoid Naringin Extends the Lifespan of.and Delays the Progression of Aging-Related Diseases in PD/AD Models via DAF-16.
Oxid Med Cell Longev. 2020 ;2020:6069354. Epub 2020 Jul 31. PMID: 32832002
Naringin is a dihydroflavonoid, which is rich in several plant species used for herbal medicine. It has a wide range of biological activities, including antineoplastic, anti-inflammatory, antiphotoaging, and antioxidative activities. So it would be interesting to know if naringin has an effect on aging and aging-related diseases. We examined the effect of naringin on the aging of(.). Our results showed that naringin could extend the lifespan of.. Moreover, naringin could also increase the thermal and oxidative stress tolerance, reduce the accumulation of lipofuscin, and delay the progress of aging-related diseases in.models of AD and PD. Naringin could not significantly extend the lifespan of long-lived mutants from genes in insulin/IGF-1 signaling (IIS) and nutrient-sensing pathways, such as-,-,-,-,-., and-. Naringin treatment prolonged the lifespan of long-lived-mutants, which have decreased reproductive stem cells. Naringin could not extend the lifespan of a null mutant of the fox-head transcription factor DAF-16. Moreover, naringin could increase the mRNA expression of genes regulated by-and itself. In conclusion, we show that a natural product naringin could extend the lifespan of.and delay the progression of aging-related diseases in.models via DAF-16.