n/a
Abstract Title:

Diosmetin inhibits the expression of alpha-hemolysin in Staphylococcus aureus.

Abstract Source:

Antonie Van Leeuwenhoek. 2015 Aug ;108(2):383-9. Epub 2015 May 29. PMID: 26021482

Abstract Author(s):

Shui Liu, Xuan Zhou, Wenhua Li, Hong Zhang, Bing Zhang, Gen Li, Bowen Liu, Xuming Deng, Liping Peng

Article Affiliation:

Shui Liu

Abstract:

Staphylococcus aureus is a significant human pathogen that causes a wide range of diseases. Alpha-hemolysin (Hla), a pore-forming cytotoxin that is produced by most S. aureus strains, can cause tissue injury and plays a critical role in the virulence of this pathogen. In the present study, we discovered that diosmetin, a natural flavonoid that occurs primarily in citrus fruits and exhibits little anti-S. aureus activity, could diminish the production of Hla in culture supernatants in a concentration-dependent manner. The analysis of cytotoxicity in the co-culture system of S. aureus and A549 epithelial cells showed that such inhibition confers significant protection against S. aureus-mediated injury. Our results suggested that diosmetin has the potential to be a new anti-virulence drug for S. aureus infection, particularly for the targeting of Hla.

Study Type : In Vitro Study

Print Options


Key Research Topics

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.