Abstract Title:

Chemical analysis and antihyperglycemic activity of an original extract from burdock root (Arctium lappa).

Abstract Source:

J Agric Food Chem. 2014 Aug 6 ;62(31):7738-45. Epub 2014 Jul 23. PMID: 24933284

Abstract Author(s):

Didier Tousch, Luc P R Bidel, Guillaume Cazals, Karine Ferrare, Jeremy Leroy, Marie Faucanié, Hugues Chevassus, Michel Tournier, Anne-Dominique Lajoix, Jacqueline Azay-Milhau

Article Affiliation:

Didier Tousch

Abstract:

In the present study, we obtained a dried burdock root extract (DBRE) rich in caffeoylquinic acids derivatives. We performed the chemical characterization of DBRE and explored its antihyperglycemic potential in both in vitro and in vivo experiments. Chemical analysis of DBRE using LC-MS and GC-MS revealed the presence of a great majority of dicaffeoylquinic acid derivatives (75.4%) of which 1,5-di-O-caffeoyl-4-O-maloylquinic acid represents 44% of the extract. In the in vitro experiments, DBRE is able to increase glucose uptake in cultured L6 myocytes and to decrease glucagon-induced glucose output from rat isolated hepatocytes together with a reduction of hepatic glucose 6-phosphatase activity. DBRE did not increase insulin secretion in the INS-1 pancreaticβ-cell line. In vivo, DBRE improves glucose tolerance both after intraperitoneal and oral subchronic administration. In conclusion, our data demonstrate that DBRE constitutes an original set of caffeoylquinic acid derivatives displaying antihyperglycemic properties.

Study Type : In Vitro Study
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