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Article Publish Status: FREE
Abstract Title:

Hop Extract Acts as an Antioxidant with Antimicrobial Effects againstand.

Abstract Source:

Molecules. 2019 Jan 9 ;24(2). Epub 2019 Jan 9. PMID: 30634461

Abstract Author(s):

Natalja Weber, Klaus Biehler, Kay Schwabe, Birgit Haarhaus, Karl-W Quirin, Uwe Frank, Christoph M Schempp, Ute Wölfle

Article Affiliation:

Natalja Weber

Abstract:

Acne is associated with hyperkeratosis, elevated levels of skin sebum and growth of() and(). Furthermore,promotes inflammation by inducing IL-6 production and oxidative stress. The aim of this study was to assess the antioxidant, anti-inflammatory and antibacterial potential of a hop-CO₂-extract with 50% humulone and lupulone. The susceptibility ofandto the hop extract was tested by using the broth microdilution technique. The minimal inhibitory concentrations (MIC) forandwere 3.1 and 9.4µg/mL, respectively. In addition, the hop extract showed an antioxidative effect with a half maximal inhibitory concentration (IC) of 29.43µg/mL as well as additional anti-inflammatory effects by reducing the IL-6 expression (IC: 0.8µg/mL). In addition, a gel formulation with 0.3% hop extract (/) had antibacterial activity againstand(inhibition zone value: 5.5 mm and 3 mm, respectively) which was significantly superior to the placebo gel. The positive control (a gel with the antibiotic clindamycin) showed an inhibition zone of 9 mm. Due to its antioxidant, anti-inflammatory and antibacterial effects hop extract might be a treatment option for acne-prone skin.

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