Abstract Title:

Acne patients frequently associated with abnormal plasma lipid profile.

Abstract Source:

J Dermatol. 2015 Mar ;42(3):296-9. Epub 2015 Jan 13. PMID: 25639454

Abstract Author(s):

Hao Jiang, Chang Yi Li, Lu Zhou, Bin Lu, Yinghui Lin, Xiaoqi Huang, Bin Wei, Qiang Wang, Leping Wang, Jianqi Lu

Article Affiliation:

Hao Jiang


This study was designed to investigate the relationship between plasma lipid profile and acne. Acne patients (n = 181) and healthy volunteers (n = 130) matched in terms of both age and sex were enrolled. Plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C) and lipoprotein (LP)(a) levels were measured. TC, LDL-C and LP(a) levels in male and female patients with severe acne were significantly higher than in the healthy control group (P<0.05). TG in male patients with severe and moderate acne was significantly higher than in the healthy control group (P<0.05). LP(a) in male and female patients with mild, moderate and severe acne was significantly higher than in the healthy control group (P<0.05). The constituent ratio of male and female patients with TC, TG, LDL-C and LP(a) over the normal range was significantly higher than in the healthy control group. In this study, acne patients were frequently associated with abnormal lipid profile, providing a new basis for further exploration of the pathogenesis, as well as new treatments, of acne vulgaris.

Study Type : Human Study

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