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Article Publish Status: FREE
Abstract Title:

The effect of electronic cigarette and tobacco smoke exposure on COPD bronchial epithelial cell inflammatory responses.

Abstract Source:

Int J Chron Obstruct Pulmon Dis. 2018 ;13:989-1000. Epub 2018 Mar 23. PMID: 29615835

Abstract Author(s):

Andrew Higham, Declan Bostock, George Booth, Josiah V Dungwa, Dave Singh

Article Affiliation:

Andrew Higham

Abstract:

Background: Electronic cigarettes (e-cigs) are used to help smoking cessation. However, these devices contain harmful chemicals, and there are safety concerns. We have investigated the effects of e-cigs on the inflammatory response and viability of COPD bronchial epithelial cells (BECs).

Methods: BECs from COPD patients and controls were exposed to e-cig vapor extract (ECVE) and the levels of interleukin (IL)-6, C-X-C motif ligand 8 (CXCL8), and lactate dehydrogenase release were measured. We also examined the effect of ECVE pretreatment on polyinosinic:polycytidylic acid (poly I:C)-stimulated cytokine release from BECs. Parallel experiments using Calu-3 cells were performed. Comparisons were made with cigarette smoke extract (CSE).

Results: ECVE and CSE caused an increase in the release of IL-6 and CXCL8 from Calu-3 cells. ECVE only caused toxicity in BECs and Calu-3 cells. Furthermore, ECVE and CSE dampened poly I:C-stimulated C-X-C motif ligand 10 release from both cell culture models, reaching statistical significance for CSE at an optical density of 0.3.

Conclusion: ECVE caused toxicity and reduced the antiviral response to poly I:C. This raises concerns over the safety of e-cig use.

Study Type : In Vitro Study
Additional Links
Adverse Pharmacological Actions : Inflammatory : CK(312) : AC(92)

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